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Deficyt CDK5 jest tylko dla tworzenia browaru, jednym aktywatorem p35 jest krytyczny dla normalnej prędkości.

Deficyt CDK5 jest tylko dla tworzenia browaru, jednym aktywatorem p35 jest krytyczny dla normalnej prędkości.

W Alzheimera chorobie CDK5 fosforyluje tau, akumulacji tau prowadzi w aksonach komórek nerwowych i apoptozy PLC.

Patologiczna (żółta) fosforylacja złota tau (czerw) z CDK5 (fiolet) prowadzi do rozpadu mikrotubul w aksonie i adiccji tau. (Juan Gaertner | Shutterstock)

Jak CDK5 i Tau?

CDK5

CDK jest białkowymi białkami kinzy serynowo-teoninowej, typowo zaangażowanymi w progresję cyklu komórkowego w komórkach eukariotycznych. Jednak CDK5, zwany także NCLK (kinaza neuronalna podobna z C2CD), jest zaangażowany w aktywną neuronalną, migrację rozwojową neuronów i wzrost neurytów.

CDK5 jest wyrażany na poziomie szkód w szkole ssaków, ale można rozwijać się tkance mięśniowej. Niedobór CDK5 może prowadzić do nieprawidłowego tworzenia móżdżku, a aktywator p35 ma kluczowego dla rozwoju. CDK5 ma różnorodną gamę substratów, w tym prawnie zaangażowane w dynamikę cytoszkieletu, adhezję komórek i transport przez błony.

Róża

Białka Tau ulegają ekspresji w neuronach ssaków, gdzie wiążą mikrotubule w aksonach. Wiążą się z mikrotubulami i promują i dodatkowe, ostatnio odkryte funkcje w sygnalizacji i organizacji cytoszkieletu. Aktywność tau jest regulowana przez jego fosforylację. Hyperphosphorylacja jego kopców jest powiązana z kilkoma chorobami neurodegeneracyjnymi, znanymi jako taupatia.

Jak CDK5 pokład na dew?

Fosforylacja CDK5 tau prowadzi do zmniejszonego wiązania z mikrotubulą. W związku z tym nie może promować tworzenia mikrotubul, co prowadzi z zarodkowania mikrotubul.

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